Excluding the graphical but manual interface, you can used DELPROF2 or GPO.
This batch delete users profile on PCs (PC01, PC02, PC03) older that 15 days
Note: DelProf2 is the equivalent of delprof tools but with support extended to the latest OS. Fortunately he have the same syntax.
Opening Group policy editor, go to:
Computer Configuration/Policy/Administrative Templates/System/User Profile
and enable the option “Delete user profiles older than a specified number of days on system restart” specifying the days.